|
| |
| Thursday |
02.02.2017 |
| |
|
| |
| 08:00 – 09:00 |
Registration, Welcome Coffee, Mounting of Posters
|
| |
| |
| 09:00 – 09:10 |
Welcome Address
Jean Gruenberg (UNIGE, President of LS2)
Didier Picard (UNIGE, Chairman of the LS2 Annual Meeting)
|
| |
| |
| 09:10 – 09:15 |
"10 years SystemsX.ch: What did we do? What did we learn?"
Daniel Vonder Mühll (Managing Director SystemsX.ch)
|
| |
|
| |
| 09:15 – 10:00 |
Plenary Lecture I
Andrew MACPHERSON
University of Bern
➤ Visit Macpherson's Lab Page
The pervasiveness of host-microbial mutualism
If we view mammals as host-microbial super-organisms, non-pathogenic microbes at body surfaces comprise 90% of the cellular load and 99% of the genetic diversity. Host and microbial metabolism are intimately integrated and the profound biological influences on almost every host organ system stem not only from signalling at mucosal surfaces and the penetration of a small proportion of live organisms into host tissues, but also the promiscuous circulation of microbial metabolic products. In this talk I shall discuss how these effects start in utero, even before the successive waves of endogenous microbial colonisation take place after birth. The functional consequences of host microbial mutualism are critical throughout the trajectory of life including shaping the innate and adaptive arms of the immune system and preparing host metabolism for the challenges of xenobiotic exposure. Despite this intimate arrangement of prokaryotic and eukaryotic metabolism, the two components are physically compartmentalised in health: I shall show how anatomic and immune firewalls set these boundaries.
|
| |
|
| |
| 10:00 – 10:30 |
Coffee Break @ Lichthof, Industry Exhibition, Poster viewing
|
| |
|
| |
| 10:30 – 12:30 |
Parallel Symposia I
|
| |
|
|
| |
|
Virology
Viruses, microbes and their hosts
Session chairs: Urs Greber (UZH) and Stefan Kunz (UNIL)
Julie Pfeiffer (University of Texas Southwestern)
How gut microbes enhance enteric virus infectivity
Jason Mercer (University College London)
tba
|
| |
|
|
| |
|
Swiss Personalized Health Network
Personalized Medecine
Session chair: Torsten Schwede (UNIBAS)
Peter Meier-Abt (president Swiss Academy of Medical Sciences, Zurich)
The Swiss Personalized Health Network (SPHN)
Russ B. Altman (Stanford University)
Informatics methods to advance personalized medicine: Focus on drugs
Cisca Wijmenga (University Medical Center Groningen)
tba
|
| |
|
|
| |
|
Tomorrow's PIs: The Future of Swiss research
Advanced Postdocs can apply to give talk in this session until 15th of November.
Please find the guidelines below.
Call for Tomorrow's PI
The selected speakers will be announced later this year.
|
| |
|
|
| |
|
Fondazione Guido Bernardini (3R)
Alternative Animal Experimentation
Session Chairs: Fabienne Chabaud (UNIL/RESAL), Marcel Gyger (EPFL)
Aaron Voigt (University Hospital, Aachen)
tba
Martin Schwarzer (Institute of Functional Genomics of Lyon (IGFL))
tba
|
| |
| |
|
| |
| 12:30 – 13:30 |
Lunch break @ Lichthof, Industry Exhibition, Poster viewing
|
| |
| |
| 12:30 – 13:30 |
LS2 Section Molecular&Cellular Biosciences Board Meeting
|
| |
|
| |
| 13:30 – 15:30 |
Parallel Symposia II
|
| |
|
|
| |
|
LS2 Section Physiology
Nutrient metabolism and disease
Session chairs: François Verrey (UZH) and Zhihong Yang (UNIFR)
Yibin Wang (University of California (UCLA))
Branched-Chain Amino Acids: Making New Friends with Old Players in Metabolism
Alaa S. Awad (Pennsylvania State University)
Arginase-2: An emerging key player in diabetic kidney disease
Nourdine Faresse (NCCR Kidney.CH Junior Grant Awardee, UZH)
Novel developments in aldosterone signaling and its role in lipid metabolism
|
| |
|
|
| |
|
Swiss Plant Science Web (SPSW)
Plant Genomics
Session chair: Kentaro Shimizu (UZH)
Hiroyuki Tsuji (Yokohama City University)
Florigen-induced epigenomic reprograming in the shoot apical meristem
Nils Stein (Leibniz Institute of Plant Genetics, Gatersleben)
Reference sequences for wheat and barley – genome size and complexity no longer a problem?
|
| |
|
|
| |
|
LS2 Section Proteomics
Structural and Functional Proteomics
Session chair: Bernd Wollscheid (ETHZ)
Martin Beck (EMBL Heidelberg)
tba
Hui Zhang (John Hopkins University)
tba
|
| |
| |
|
| |
| 15:30 – 16:00 |
Coffee Break @ Lichthof, Industry Exhibition, Poster viewing
|
| |
|
| |
| 16:00 – 16:30 |
Friedrich-Miescher Award Lecture
The winner will be announced later this year.
|
| |
|
| |
| 16:30 – 17:20 |
Plenary Lecture II
Sally TEMPLE
Neural Stem Cell Institute, NY
➤ Visit Temple's Lab Page
Temporal programs in neural stem cell development and aging
Neural stem cells (NSCs) are foundational cells in mammalian central nervous system development, and they continue to contribute new neurons and glial cells throughout life in areas of the adult brain important for learning and memory. During development, NSCs produce diverse progeny on a precise time-schedule. For example, during cerebral cortical development, they produce layer-specific neurons in order, from deep to superficial, prior to generating glia. Notably, these temporal changes are programmed within individual progenitor cells , as they can be recapitulated by single cells isolated from the brain and dividing in clonal culture, shown by following cell lineages by time-lapse analysis. In the adult brain, temporal changes also dominate NSC behavior, as they deplete during aging, contributing to memory impairment. Our work is aimed at understanding how NSC gene pathways and networks change over time in mice and human, to provide insight into fundamental neural developmental and aging mechanisms, and how they may lead to congenital defects and age-related neurodegenerative disease.
|
| |
| |
| 17:20 – 17:30 |
Crowdfunding your research: test ideas, spread knowledge
wemakeit.com
Speakers: Luc Henry and Mirko Bischofsberger
|
| |
|
| |
| 17:30 – 19:30 |
Poster session & Musical Apéro @ Lichthof
Poster session accompanied by an Apéro and the Soul Trio "Soulpotion".
|
| |
| |
| 18:00 – 19:30 |
LS2 Delegates Assembly
|
| |
|
| |
| |
|
| |
| Friday |
03.02.2017 |
| |
|
| |
| 09:10 – 10:00 |
EMBO Keynote Lecture
Bernd BUKAU
Center for Molecular Biology (ZMBH), University of Heidelberg
➤ Visit Bukau's Lab Page
The busy life of nascent chains: Mechanisms of folding and assembly of newly synthesized proteins
The process of translation integrates multiple tightly regulated mechanisms ensuring that nascent polypeptide chains are correctly processed, targeted and folded into functional proteins. These include co-translationally acting factors, some of which associate transiently to ribosomes, which mediate spatially and temporally orchestrated protein maturation steps, and mRNA-encoded local translation speed variations which appear to guide these processes. Pro- and eukaryotes share basic principles but differ with respect to major features including the nature of the involved factors, indicating substantial evolutionary diversification. We report the dissection of the flux of newly synthesized proteins through the system of co-translationally engaged factors in E. coli and S. cerevisiae using ribosome profiling technology. In E. coli, the SRP targets almost exclusively inner membrane proteins to the membrane, whereas the chaperone trigger factor (TF) associates primarily with cytosolic, periplasmic and outer membrane proteins, indicating nascent chains are triaged between SRP and TF pathways. The Hsp70 chaperone DnaK interacts in concerted action with TF, typically with longer nascent chains and and reflecting domain boundaries of the emerged nascent chains. We also find evidence that assembly of protein complexes initiates co-translationally once the domain interfaces of the interacting polypeptides are exposed. The organisation of the subunit-encoding genes in operons facilitates the assembly process. In S. cerevisiae the Hsp70 chaperone Ssb shows a different pattern of early nascent chain association as compared to its prokaryotic DnaK counterpart. Co-translational protein assembly is also observed, although operon organisation of genes is less common, pointing to differences in the principles governing protein assembly in pro- and eukaryotes.
|
| |
| |
| 10:00 – 10:05 |
PACE PostDoc Association
|
| |
|
| |
| 10:05 – 10:30 |
Coffee Break @ Lichthof, Industry Exhibition, Poster viewing
|
| |
|
| |
| 10:30 – 12:30 |
Parallel Symposia III
|
| |
|
|
| |
|
LS2 Section Molecular and Cellular Biosciences
From cell biology to single molecules
Session chair: Monica Gotta (UNIGE)
Lori Passmore (University of Cambridge)
Regulation of polyA tail length by cellular machines
Buzz Baum (University College London)
The evolution of eukaryotic cell division
TakaraClontech
tba
|
| |
|
|
| |
|
Cellular Immunology
Session Chair: Salomé Leibundgut (UZH)
Venizelos Papayannopoulos (The Francis Crick Institute, London)
Neutrophil extracellular traps in immunity and disease
Lynn Wong (UZH)
Inhibitors of apoptosis proteins in host defense from infection
Tobias Junt (Novartis Institutes for Biomedical Research, Basel)
GPR91 – a metabolic switch in autoimmune inflammation
|
| |
|
|
| |
|
SCNAT Forum for Genetic Research
Misuse of biological research: How can we prevent biocrimes?
Session Chair: Ursula Jenal (Jenal & Partners Biosafety Consulting, Rheinfelden)
Cédric Invernizzi (Federal Office for Civil Protection (FOCP),
SPIEZ LABORATORY, Spiez/CH)
When export controls interfere with the publication of scientific research: The dual use problem
Following the talk by Cédric Invernizzi, an interdisciplinary panel of young scientists will evaluate and discuss different options on how to address the misuse potential of biological research. All are welcome to join the discussion!
|
| |
|
|
| |
|
Satellite Workshop
Non-academic careers in the Life Sciences
Session chair: Ulrike Rieder (Philochem AG)
Starting with a Start-up
Careers in Pharma
Scientific Management
Speakers working in the respective domain will give a brief 5' introduction about their career path and will then be available for the following 1 hour-round table discussion.
|
| |
| |
|
| |
| 12:30 – 14:00 |
Lunch break @ Lichthof, Industry Exhibition, Poster viewing
|
| |
|
| |
| 14:00 – 16:00 |
Parallel Symposia IV
|
| |
|
|
| |
|
Experimental Pharmacology
New Drugs for Pain, Sleep, and Memory? From Basic Mechanisms to Clinical Implications
Session Chair: Hans-Peter Landolt (UZH)
Hanns Ulrich Zeilhofer (University of Zurich)
New Approaches to Chronic Pain
William Wisden (Imperial College London)
Capturing the neuronal ensembles underlying sleep and sedation
Dominique de Quervain (University of Basel)
Genes and Memory: New Approaches in Drug Discovery
|
| |
|
|
| |
|
Anatomy, Histology and Embryology
Cellular scissors- new perspectives on proteases
Session Chair: Franziska Theilig (University of Fribourg)
Thomas Reinheckel (University of Freiburg)
Lysosomal Proteases and Cancer Progression - how does it work?
Edith Hummler (University of Lausanne)
Serine proteases in health and disease
|
| |
|
|
| |
|
Satellite Workshop
Academic Careers in the Life Sciences
Session chair: Ulrike Rieder (Philochem AG)
Young Academia
From Industry back to Academia
Established Academia
Speakers working in the respective domain will give a brief 5' introduction about their career path and will then be available for the following 1 hour-round table discussion.
|
| |
| |
|
| |
| 16:00 – 16:30 |
Coffee Break @ Lichthof, Industry Exhibition, Poster viewing
|
| |
|
| |
| 16:30 – 17:15 |
Award session
|
| |
|
Lelio Orci Award
|
| |
|
Poster Awards
|
| |
|
Tomorrow's PI Award
|
| |
| |
|
| |
| 17:15 – 18:10 |
Plenary Lecture III
Denis DUBOULE
University of Geneva and EPFL
➤ Visit Duboule's Lab Page
Hox Genes Regulation During Vertebrate Development and Evolution
Unlike in invertebrates, vertebrate Hox gene clusters are found in multiple copies and are tightly packed and organized, with all transcripts encoded by the same DNA strand. This vertebrate genomic synapomorphy has been largely verified by recent genome sequencing efforts and an exception to this rule has not been found thus far. This evolutionary conundrum can be tentatively explained when considering recent work on the various regulatory strategies implemented by these genomic loci. By using recent data addressing these issues, I will try and propose a model for this surprising observation.
|
| |
| |
| 18:10 – 18:15 |
Closing remarks
Jean Gruenberg (UNIGE, President of LS2)
Didier Picard (UNIGE, Chairman of the LS2 Annual Meeting)
|
| |
|
